Key role of CXCL13/CXCR5 axis for cerebrospinal fluid B cell recruitment in pediatric OMS

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• 作者：Michael R. Pranzatelli^a ; ^b ; ^{mpranzatelli@siumed.edu} ; ; Elizabeth D. Tate^a ; ^b ; Nathan R. McGee^a ; ^b ; Anna L. Travelstead^c ; Richard M. Ransohoff^d ; Jayne M. Ness^e ; Jerry A. Colliver^f
• 关键词：ACTH ; adrenocorticotrophic hormone or corticotropin ; CSF ; cerebrospinal fluid ; CXCL12 ; stromal-derived factor ; CXCL13 ; B cell attractant-1 ; IQR ; interquartile range ; IVIG ; intravenous immunoglobulins ; MS ; multiple sclerosis ; OMS ; opsoclonus&ndash ; myoclonu
• 刊名：Journal of Neuroimmunology
• 出版年：2012
• 出版时间：29 February 2012
• 年：2012
• 卷：243
• 期：1-2
• 页码：81-88
• 全文大小：936 K

文摘

To study aberrant B cell trafficking into the CSF in opsoclonus-myoclonus syndrome (OMS), chemoattractants CXCL13 and CXCL12, and B cell frequency and CXCR5 expression, were evaluated. CSF CXCL13 concentration and the CSF/serum ratio were higher in untreated OMS than controls, related directly to OMS severity and inversely to OMS duration, and correlated with CSF B cell frequency and oligoclonal bands. CXCL12 showed the opposite pattern. Selective accumulation of CXCR5 + memory B cells in CSF was found. In ACTH-treated OMS, CXCL13, but not CXCL12, was lower. These data implicate the chemokine/chemoreceptor pair CXCL13/CXR5 in B cell recruitment to the CNS in OMS. CXCL13 and CXCL12 may serve as reciprocal biomarkers of disease activity, but CXCL13 also had utility as a treatment biomarker.