Association of PDCD1 polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibility

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• 作者：Luisa Matos do Canto^a ; ¹ ; Ticiana Della Justina Farias^a ; ¹ ; Mayara Delagnelo Medeiros^a ; Cí ; ntia Callegari Coê ; lho^a ; Aline Fernanda Rodrigues Sereia^a ; Lia Kubelka Fernandes de Carlos Back^a ; Filipe Martins de Mello^b ; Adriana Fontes Zimmermann^c ; Ivâ ; nio Alves Pereira^c ; Ilí ; ada Rainha de Souza^a ; ^{iliadarainha@gmail.com}
• 关键词：Rheumatoid arthritis ; Systemic lupus erythematosus ; Autoimmunity ; PDCD1 gene ; PD1.3 polymorphism
• 刊名：Revista Brasileira de Reumatologia (English Edition)
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：56
• 期：6
• 页码：483-489
• 全文大小：816 K
• 卷排序：56

文摘

This study aims to analyze the relationship of programmed cell death 1 (PDCD1) gene polymorphism (PD1.3G/A – rs11568821) with features of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in a Southern Brazilian population.MethodsPolymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed in 95 SLE and 87 RA patients and 128 control group individuals from Santa Catarina, Southern Brazil. The Hardy–Weinberg equilibrium (HWE) test, and odds ratio (OR) were analyzed, considering CI 95% and p ≤ 0.05.ResultsThe PD1.3A allele frequencies were 0.095 (SLE), 0.115 (RA) and 0.078 (controls). The genotypes of the control group were in HWE, while those of SLE and RA patients were not. However, we found no association between PD1.3 polymorphism and the SLE or RA susceptibility, nor clinical or epidemiological data.ConclusionThere was no significant association between PD1.3 polymorphism and SLE or RA susceptibility in this Southern Brazilian population.