Advances in quantitative proteomics using stable isotope tags

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• 作者：Flory ; Mark R. ; Griffin ; Timothy J. ; Martin ; Daniel ; Aebersold ; Ruedi
• 关键词：proteome ; profile ; isotope dilution ; ICATTM ; quantitative mass spectrometry ; liquid chromatography
• 刊名：Trends in Biotechnology
• 出版年：2002
• 出版时间：December 1, 2002
• 年：2002
• 卷：20
• 期：12
• 页码：s23-s29
• 全文大小：247 K

文摘

This article describes recent technological developments that now permit the quantitative measurement of global changes in proteome profiles. This is expected to aid in understanding biological mechanisms and to reveal diagnostic indicators for disease.