Water clusters in the nucleotide-binding pocket of the protein aIF2γ from the archaeon Sulfolobus solfataricus: Proton transmission
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- 作者：Oleg Nikonov ; alik@vega.protres.ru" class="auth_mail" title="E-mail the corresponding author ; Olesya Kravchenko ; Valentina Arkhipova ; Elena Stolboushkina ; Stanislav Nikonov ; Maria Garber
- 关键词：Crystal structure ; GTP hydrolysis ; G-protein ; a/eIF2 ; Proton transition ; Water clusters
- 刊名：Biochimie
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：121
- 期：Complete
- 页码：197-203
- 全文大小：3856 K
文摘
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The structure of SsoaIF2γ in complex with analog GTP, GDPCP, is submitted.
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Its nucleotide-binding pocket is similar to that of ribosome-bound EF-Tu.
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The pocket is stabilized by three water clusters shielding GDPCP from the solvent.
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Two water bridges could transmit protons arising from the catalytic reaction.