Aescin reduces oxidative stress and provides neuroprotection in experimental traumatic spinal cord injury
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- 作者：Peng Chenga ; b ; chengpengfmmu@126.com" class="auth_mail" title="E-mail the corresponding author ; Fang Kuanga ; Gong Jua ; jugong@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：SCI ; spinal cord injury ; LPO ; lipid peroxidation ; NO ; nitric oxide ; ; NOx ; nitrate/nitrite ; MMPs ; matrix metalloproteases ; MDA ; malondialdehyde ; 4-HNE ; 4-hydroxynonenal ; T8 ; the 8th thoracic ; dpi ; days post injury ; BBB ; Basso-Beattie-Bresnahan ; 8-OhdG ; 8-hydroxydeoxyguanosine ; MPO ; myeloperoxidase ; 3-NT ; 3-nitrotyrosine ; iNOS ; inducible nitric oxide synthases ; MBP ; myelin basic protein ; NF-κB ; nuclear factor κB ; p-NF-κB ; phosphorylated nuclear factor κB ; HO-1 ; haem oxygenase 1 ; RT ; room temperat
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：405-417
- 全文大小：5060 K
文摘
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Aescin improves behavioural outcomes after spinal cord injury (SCI).
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Aescin alleviates immune cell infiltration, decreases MMP3 and MMP9 enzyme levels and reduces NO production after SCI.
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Aescin restricts oxidative stress and damage to macromolecules after SCI.
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Aescin reduces neuronal loss, demyelination, tissue destruction, oedema and apoptosis after SCI.
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Aescin increases expression of HO-1 and suppresses activation of the NF-κB pathway after SCI.