Targeted temperature management for acute encephalopathy in a Japanese secondary emergency medical care hospital

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• 作者：Shinya Murata^a ; Mitsuru Kashiwagi^a ; ^{dbs003@art.osaka-med.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Takuya Tanabe^b ; Chizu Oba^a ; Seiji Shigehara^a ; Satoshi Yamazaki^a ; Atsuko Ashida^a ; Akihiko Sirasu^a ; Keisuke Inoue^a ; Keisuke Okasora^a ; Hiroshi Tamai^c
• 关键词：Acute encephalopathy ; Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) ; Normothermia ; Hypothermia ; Status epilepticus ; Secondary emergency medical care ; Targeted temperature management
• 刊名：Brain and Development
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：38
• 期：3
• 页码：317-323
• 全文大小：281 K

文摘

The goals of this study, conducted in our secondary emergency care hospital, were to assess the effectiveness of targeted temperature management (TTM) for acute encephalopathy secondary to status epilepticus and to consider appropriate adaptations for use of TTM in this setting.

Methods

Medical records of patients admitted with acute encephalopathy to Hirakata City Hospital between January 2010 and December 2014 were retrospectively reviewed. Cases treated with TTM (36 °C) and methylprednisolone pulse (MP) therapy (TTM/MP) were compared with those treated with conventional MP regarding clinical courses and outcomes.

Results

In total, 20 children were retrospectively enrolled. In the TTM/MP group (10 cases) all survived intact. In the MP group (10 cases), 4 cases were left with neurological sequelae. Furthermore, in the TTM/MP group, the body temperature dropped more quickly. For pediatricians in this secondary emergency hospital, implementing the body temperature management system was not difficult. There were no complications caused by hypothermia.

Discussion

Use of TTM as the initial treatment for acute encephalopathy in the early-onset stage is possible in a secondary emergency care hospital. However, some acute encephalopathy cases are the so-called fulminant type; DIC or shock develops soon after onset and so it is sometimes difficult to introduce TTM. Fulminant-type patients should be transported to tertiary emergency care hospitals. Secondary emergency care hospitals must carefully select cases for TTM, keeping the possibility of transport to a tertiary emergency hospital in mind at all times.