Hippocampal signal abnormality on the first day of illness in acute encephalopathy with biphasic seizures and late reduced diffusion caused by HHV-6 infection

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• 作者：Takuya Matsuda ; Shuichi Shimakawa ; ^{ZVQ10523@nifty.com" class="auth_mail" title="E-mail the corresponding author} ; Hiromitsu Toshikawa ; Mari Hatanaka ; Miho Fukui ; Atsushi Mori ; Hiroshi Tamai
• 关键词：Febrile status epilepticus ; Hippocampal injury ; Human herpesvirus-6 ; Acute encephalopathy with biphasic seizures and late reduced diffusion ; Diffusion-weighted image
• 刊名：Brain and Development
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：38
• 期：10
• 页码：943-946
• 全文大小：1037 K

文摘

We report a 13-month-old girl who developed acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) with transient reduced diffusion in the hippocampus and anterior commissure on diffusion-weighted imaging (DWI), which was performed on the first day after febrile status epilepticus (FSE) as the initial neurological symptom of AESD. DWI just after late seizures showed high signal intensity lesions in both left hippocampus and anterior commissure, and left extratemporal and occipital subcortical white matter. HHV-6 DNA was positive in both blood and cerebrospinal fluid samples. DWI at two months after onset showed atrophy in the left mesial temporal lobe and extratemporal and occipital lobe without the signal abnormalities.

Although it has been reported that magnetic resonance images tend to show no acute abnormality during the first two days in typical AESD, transient reduced diffusion could be found on the DWI performed on the first day of AESD.