Interventional therapy of diabetes mellitus type 2 complicated with acute cerebral hemorrhage by using dexmedetomidine

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• 作者：Shan-Shan Zheng^# ; Xin-Ye Qian^# ; Si-Yuan Li ; Xuan Zhao ; ^{zhaoxuan0323@sina.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Dexmedetomidine ; Diabetes mellitus ; Interventional therapy ; Acute cerebral hemorrhage
• 刊名：Journal of Acute Disease
• 出版年：2016
• 出版时间：1 September 2016
• 年：2016
• 卷：5
• 期：5
• 页码：419-422
• 全文大小：278 K

文摘

To study the effects of dexmedetomidine on cerebral injury, inflammation, oxidative stress and renal function of patients with diabetes mellitus type 2 complicated with acute cerebral hemorrhage.

Methods

A total of 98 cases who had been diagnosed with diabetes mellitus type 2 complicated with acute cerebral hemorrhage and treated with interventional therapy in Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from September 2014 January 2016 were chosen to be our study subjects. Among them, 50 cases given dexmedetomidine treatment in the process of anesthesia were included in the dexmedetomidine group (Group A), while the other 48 cases treated with equal amount of normal saline were considered as the negative control group. The postoperative cerebral injury indexes and the serum biochemical indexes were detected after 24 h.

Results

The contents of serum S100β [(2.1 ± 0.2) μg/L] and neuron-specific enolase (NSE) [(14.2 ± 1.3) μg/mL] in Group A were all significantly lower than serum S100β [(2.9 ± 0.3) μg/L] and NSE [(16.6 ± 1.7) μg/mL] of patients in negative control group. The contents of cerebrospinal fluid S100β [(0.9 ± 0.1) μg/L] and NSE [(10.7 ± 1.3) μg/mL] in Group A were all significantly lower than cerebrospinal fluid S100β [(1.3 ± 0.2) μg/L] and NSE [(15.3 ± 1.7) μg/mL] of patients in negative control group. The contents of erythrocyte sedimentation rate [(11.7 ± 2.5) mm/h], c-reactive protein [(2.3 ± 0.4) mg/L], urea nitrogen [(10.7 ± 1.2) mmol/L] and serum creatinine [(151.6 ± 14.9)] μmol/L in Group A were all significantly lower than erythrocyte sedimentation rate [(23.6 ± 3.8) mm/h], c-reactive protein [(6.9 ± 1.1) mg/L], urea nitrogen [(16.7 ± 1.7) mmol/L] and serum creatinine [(192.5 ± 18.3)] μmol/L of patients in negative control group.

Conclusions

The application of dexmedetomidine in the interventional therapy of diabetes mellitus type 2 complicated with acute cerebral hemorrhage could protect brain and renal functions and reduce systemic inflammatory responses.