Failure to interact with Brd4 alters the ability of HPV16 E2 to regulate host genome expression and cellular movement
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- 作者：Elaine J. Gausona ; b ; Xu Wanga ; Edward S. Dornanb ; Pawel Herzykd ; e ; Molly Bristola ; Iain M. Morgana ; c ; immorgan@vcu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Human papillomavirus ; E2 ; Brd4 ; Cancer ; Exon array ; Affymetrix
- 刊名：Virus Research
- 出版年：2016
- 出版时间：4 January 2016
- 年：2016
- 卷：211
- 期：Complete
- 页码：1-8
- 全文大小：1224 K
文摘
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The results describe a role for Brd4 in HPV16 E2 regulation of the host genome.
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Highly down regulated genes are not significantly changed but activated genes are.
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The results demonstrate that an interaction between HPV16 E2 and Brd4 is involved in co-activating a set of host genes.
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Overall the results suggest that the levels of Brd4, or its ability to interact with E2, could determine infection outcome.