Nickel (II) complexes of naphthaquinone thiosemicarbazone and semicarbazone: Synthesis, structure, spectroscopy, and biological activity
详细信息 查看全文
- 作者：Afrasiabi ; Zahra ; Sinn ; Ekk ; Lin ; Weisheng ; Ma ; Yinfa ; Campana ; Charles ; Padhye ; Subhash
- 关键词：1 ; 2-Naphthaquinone ; Thiosemicarbazone ; Nickel complexes ; Biological activity ; MCF-7 breast cancer cells
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2005
- 出版时间：July, 2005
- 年：2005
- 卷：99
- 期：7
- 页码：1526-1531
- 全文大小：222 K
文摘
Ni(II) complexes of ortho-naphthaquinone thiosemicarbazone and semicarbazone were synthesized and spectroscopically characterized. The X-ray crystal structure of both the complexes describe a distorted octahedral coordination with two tridentate mono-deprotonated ligands. In vitro anticancer studies on MCF-7 human breast cancer cells reveal that the semicarbazone derivative along with its nickel complex is more active in the inhibition of cell proliferation than the thiosemicarbazone analogue.