Transition metal complexes of phenanthrenequinone thiosemicarbazone as potential anticancer agents: synthesis, structure, spectroscopy, electrochemistry and in vitro anticancer activity against human breast cancer cell-line, T47D

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• 作者：Zahra Afrasiabi ; Ekk Sinn ; Shreelekha Padhye ; Sabari Dutta ; Subhash Padhye ; Chris Newton ; Christopher E. Anson ; Annie K. Powell
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2003
• 出版时间：1 July 2003
• 年：2003
• 卷：95
• 期：4
• 页码：306-314
• 全文大小：507 K

文摘

The thiosemicarbazone derivative of 9,10-phenanthrenequinone, 1, and its metal complexes were synthesized. The X-ray crystal structure for 1 confirms the presence of the E tautomeric arrangement in this compound. Its copper complex shows 1:1 stoichiometry while nickel and cobalt compounds show 1:2 stoichiometry. The X-ray crystal structure of the nickel complex indicates two tridentate ligands coordinating in the thiolato form yielding an octahedral geometry for the ‘mer’ isomer. The copper complex exhibits maximum antiproliferative activity against human breast cancer cell-line, T47D probably due to inhibition of steroid binding to the cognative receptor or by preventing dimerization of the estrogen receptor.