Modulatory effects of catechin hydrate against genotoxicity, oxidative stress, inflammation and apoptosis induced by benzo(a)pyrene in mice
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- 作者：Ayaz Shahid ; Rashid Ali ; Nemat Ali ; Syed Kazim Hasan ; Preeti Bernwal ; Shekh Mohammad Afzal ; Abul Vafa ; Sarwat Sultana ; sarwat786@rediffmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Benzo(a)pyrene ; Catechin hydrate ; Genotoxicity ; Apoptosis ; Histopathology
- 刊名：Food and Chemical Toxicology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：92
- 期：Complete
- 页码：64-74
- 全文大小：4944 K
文摘
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Catechin protects against genotoxicity by modulating CYPOR and mEH enzymes.
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Genotoxicity, oxidative stress, inflammation and apoptosis may be the plausible mechanisms behind benzo(a)pyrene-induced toxicity.
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Role of catechin hydrate in suppressing histopathological changes induced by benzo(a)pyrene.
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Catechin hydrate increased activities of tissue anti-oxidant armory (SOD, CAT, GPx, GR, GST, QR and GSH).