Copper catalyzed direct aerobic double-oxidative cross-dehydrogenative coupling of imidazoheterocycles with aryl acetaldehydes: an articulate approach for dicarbonylation at C-3 position

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• 作者：S. M. Abdul Shakoor ; Devesh S. Agarwal ; Anil Kumar ; Rajeev Sakhuja ; ^{sakhuja.rajeev@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Aryl acetaldehyde ; Imidazo[1 ; 2-a]pyridine ; Oxidative ; Cross-dehydrogenative coupling ; Aerobic
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：4 February 2016
• 年：2016
• 卷：72
• 期：5
• 页码：645-652
• 全文大小：812 K

文摘

Direct aerobic oxidative cross-dehydrogenative coupling of aryl acetaldehydes at C-3 position of imidazoheterocycles via copper catalyzed reaction resulted in the synthesis of dicarbonylated imidazoheterocycles in 55–85% yields. The methodology provides a straightforward, high yielding and one-pot approach towards the synthesis of C-3 dicarbonylated imidazoheterocycles without prior activation of C(sp²)-H or a base. This also reports the first method of coupling of aryl acetaldehydes on imidazo[1,2-a]pyridine system via double-oxidative cross-dehydogenative process.