Evaluation of steroidal amines as lipid raft modulators and potential anti-influenza agents

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• 作者：Sameer Agarwal ; Cornelia Schroeder ; Georg Schlechtingen ; Tobias Braxmeier ; Gary Jennings ; Hans-Joachim Kn?lker
• 关键词：Antiviral activity ; Influenza ; Lipid rafts ; Raft modulators ; Steroidal amines
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2013
• 出版时间：15 September, 2013
• 年：2013
• 卷：23
• 期：18
• 页码：5165-5169
• 全文大小：1860 K

文摘

The influenza A virus (IFV) possesses a highly ordered cholesterol-rich lipid envelope. A specific composition and structure of this membrane raft envelope are essential for viral entry into cells and virus budding. Several steroidal amines were investigated for antiviral activity against IFV. Both, a positively charged amino function and the highly hydrophobic (C log P ? 5.9) ring system are required for IC₅₀ values in the low ¦ÌM range. An amino substituent is preferential to an azacyclic A-ring. We showed that these compounds either disrupt or augment membrane rafts and in some cases inactivate the free virus. Some of the compounds also interfere with virus budding. The antiviral selectivity improved in the series 3-amino, 3-aminomethyl, 3-aminoethyl, or by introducing an OH function in the A-ring. Steroidal amines show a new mode of antiviral action in directly targeting the virus envelope and its biological functions.