The calcineurin-NFAT pathway controls activity-dependent circadian gene expression in slow skeletal muscle
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- 作者：Kenneth A. Dyar1 ; 7 ; kenneth.dyar@helmholtz-muenchen.de" class="auth_mail" title="E-mail the corresponding author ; Stefano Ciciliot1 ; Guidantonio Malagoli Tagliazucchi2 ; 6 ; Giorgia Pallafacchina1 ; 4 ; Jana Tothova1 ; Carla Argentini1 ; Lisa Agatea1 ; Reimar Abraham1 ; Miika Ahdesmä ; ki5 ; Mattia Forcato2 ; Silvio Bicciato2 ; Stefano Schiaffino1 ; 4 ; Bert Blaauw1 ; 3 ; bert.blaauw@unipd.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Skeletal muscle ; Circadian ; Activity ; NFAT
- 刊名：Molecular Metabolism
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：4
- 期：11
- 页码：823-833
- 全文大小：1827 K
文摘
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Activity is a major extrinsic factor driving ∼15% of muscle circadian genes.
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Calcineurin-NFAT drives activity-dependent circadian gene expression in muscle.
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The majority of skeletal muscle circadian genes are muscle type-specific.
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A common set of skeletal muscle circadian genes are clock-dependent.