Association of the (TAAAA)n repeat polymorphism of SHBG gene with the age at menopause in Greek postmenopausal women

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• 作者：Anastasia E. Markatseli^a ; Elissavet Hatzi^b ; Christina Pamporaki^a ; Ioanna Bouba^b ; Nectaria Xita^a ; Stelios Tigas^a ; Ioannis Georgiou^b ; Agathocles Tsatsoulis^a ; ^{atsatsou@uoi.gr" class="auth_mail}
• 关键词：BMI ; body mass index ; LD ; linkage disequilibrium ; PCOS ; polycystic ovary syndrome ; PNRP ; pentanucleotide repeat polymorphism ; SHBG ; sex hormone-binding globulin
• 刊名：Maturitas
• 出版年：June 2014
• 年：2014
• 卷：78
• 期：2
• 页码：113-116
• 全文大小：420 K

文摘

To assess the potential association of the pentanucleotide (TAAAA)n repeat polymorphism in the promoter of SHBG gene with the age at menopause in a Greek female population.

Study design

Cross-sectional study. Two hundred and ten postmenopausal women aged 46–63 years were enrolled. The age at the last menstrual period and anthropometric parameters were recorded in all participants. Blood sampling for genotyping of the (TAAAA)n polymorphism of SHBG gene was performed.

Main outcome measure(s)

Frequency and association of the (TAAAA)_n alleles with age at menopause.

Results

The alleles with seven and eight TAAAA repeats were associated with the age at menopause. The age at menopause was higher in carriers than in non-carriers of the (TAAAA)₇ allele (50.2 ± 3.1 years vs. 48.0 ± 4.8 years, p = 0.026). Furthermore, the age at menopause was lower in women carrying the (TAAAA)₈ allele (47.5 ± 4.8 years) than in women not carrying this allele (48.8 ± 4.4 years, p = 0.048).

Conclusions

The (TAAAA)₇ and (TAAAA)₈ alleles of the SHBG (TAAAA)_n polymorphism may contribute to variation in the timing of natural menopause in postmenopausal women of Northwestern Greece.