Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease
Novel aurone Mannich base derivatives were synthesized. Most compounds showed good acetylcholinesterase inhibitory and antioxidant activity. Some compounds exhibited significant inhibition of self- or Cu2+-induced Aβ aggregation. 7d and 7m were the outstanding representatives with good multifunctional properties. Compound 7d was more excellent than donepezil and showed neuroprotective effect.