Drastic acceleration of fibrillation of insulin by transient cavitation bubble

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• 关键词：Aggregation acceleration ; Transient bubbles ; Subharmonic wave ; Amyloid fibril ; Acoustic field analysis
• 刊名：Ultrasonics Sonochemistry
• 出版年：2017
• 出版时间：May 2017
• 年：2017
• 卷：36
• 期：Complete
• 页码：206-211
• 全文大小：1426 K
• 卷排序：36

文摘

Fibrillation of insulin is accelerated by a factor 430 with ultrasonic irradiation. It is caused by cavitation bubble, not by temperature increase of bulk solution. This phenomenon highly contributes to diagnosis and drug discovery of amyloidosis.