Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation
文摘
Novel multi-target-directed ligands against Alzheimer's disease were designed. Activity against eeAChE, eqBuChE, hBACE1 and Aβ-aggregation was tested. Two derivatives: 26 and 52 with interesting pharmacological profiles were selected.