Spray-dried Eudragit® L100 microparticles containing ferulic acid: Formulation, in vitro cytoprotection and in vivo anti-platelet effect
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- 作者：Jessica Mendes Nadala ; Mona Lisa Simionatto Gomesa ; Dé ; bora Maria Borsatob ; Martinha Antunes Almeidac ; Fernanda Malaquias Barbozab ; Sô ; nia Faria Zawadzkic ; Carla Cristine Kanunfred ; Paulo Vitor Faragob ; pvfarago@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sandra Maria Warumby Zanina
- 关键词：Anti-inflammatory ; Antioxidant ; Methacrylic polymer ; Phytoalexin ; Platelet aggregation
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：64
- 期：Complete
- 页码：318-328
- 全文大小：2240 K
文摘
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Ferulic acid-loaded Eudragit® L100 microparticles with high drug-loading were obtained.
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Spray-dried Eudragit® L100 microparticles containing ferulic acid showed improved in vitro cytoprotective effect.
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Ferulic acid spray-dried microparticles had potential as in vitro anti-inflammatory and immunomodulatory.
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In vivo studies demonstrated an enhanced antiplatelet effect for ferulic acid-loaded Eudragit® L100 microparticles.