Agkihpin, a novel SVTLE from Gloydius halys Pallas, promotes platelet aggregation in vitro and inhibits thrombus formation in vivo in murine models of thrombosis
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- 作者：Huiqiong Xiea ; 1 ; Miao Huangb ; 1 ; Qiping Hua ; huqiping@gxmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Kejian Suna ; Huayu Wua ; Wei Shua ; Xiaolong Lia ; Ling Fanga
- 关键词：Agkihpin ; Snake venom thrombin-like enzyme (SVTLE) ; Molecular cloning ; Platelets aggregation ; Fibrino(gen)olytic activities ; Thrombosis
- 刊名：Toxicon
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：78-88
- 全文大小：4371 K
文摘
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2Leu(Tyr), 4Asn and 121Ile in amino acid sequence of agkihpin were first found in the amino acid sequences of SVTLEs.
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With fibrino(gen)olytic, thrombosis-reduced and unbleeding activities, agkihpin may be developed as a thrombolytic drug.
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The effect of agkihpin might enhance the ADP-induced platelet aggregation by a superimposed effect.