Suppression of TLRs signaling pathways by 1-[5-methoxy-2-(2-nitrovinyl)phenyl]pyrrolidine
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- 作者：Sang-Il Ahna ; Ji-Soo Kima ; Hyeon-Myeong Shinb ; Ah-Yeon Kimb ; Gyo-Jeong Gua ; Hyun-Jin Shimb ; Yeon Joo Kimc ; Kwang Oh. Kohc ; Joo Yang Mangc ; Dae Young Kimc ; Hyung-Sun Youna ; b ; hyoun@sch.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：1-[5-methoxy-2-(2-nitrovinyl)phenyl]pyrrolidine ; MyD88 ; Nuclear factor-κB ; Toll-like receptor ; TRIF
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：35
- 期：Complete
- 页码：193-200
- 全文大小：908 K
文摘
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Inflammation is involved in numerous diseases.
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Toll-like receptors (TLR) play a significant role in the induction of innate immune responses
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1-[5-methoxy-2-(2-nitrovinyl)phenyl]pyrrolidine is abbreviated to MNP.
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MNP inhibited the NF-κB and IRF3 activation and COX-2, iNOS, and IP-10 expression induced by TLR agonists.
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These results suggest that MNP can modulate MyD88- and TRIF-dependent signaling pathways of TLRs.