Increase in c-Fos and Arc protein in retrosplenial cortex after memory-improving lateral hypothalamic electrical stimulation treatment
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- 作者：Elisabeth Ká ; dá ; rb ; Eva Vico-Varelaa ; c ; Laura Aldavert-Veraa ; Gemma Huguetb ; Ignacio Morgado-Bernala ; Pilar Segura-Torresa ; pilar.segura@uab.cat" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ac ; acquisition ; AP ; antero-posterior ; aRSC ; agranular retrosplenial cortex ; BLA ; basolateral amygdala ; CA1 ; CA1 region of the hippocampus ; CA3 ; CA3 region of the hippocampus ; CS ; conditioned stimulus ; DAB ; 3 ; 3&prime ; -diaminobenzidine ; gRSC ; granular retrosplenial cortex ; ICSS ; intracranial self-stimulation ; LA ; lateral amygdala ; LH ; lateral hypothalamus ; OI ; optimum current intensity of ICSS ; PBS ; phosphate buffered saline ; ROI ; region of interest ; RSC ; retrosplenial cortex ; Rt ; retention ; rt
- 刊名：Neurobiology of Learning and Memory
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：128
- 期：Complete
- 页码：117-124
- 全文大小：1190 K
文摘
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ICSS increased bilaterally c-Fos in gRSC and aRSC at all layers.
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TWAA acquisition and retention increased c-Fos widely in gRSC and aRSC.
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ICSS potentiates the c-Fos induction across TWAA conditions in V layer of the gRSC.
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Increased protein Arc after ICSS in ipsilateral gRSC is shown for the first time.
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We suggest that gRSG could be involved in the positive modulatory effects of ICSS on memory consolidation.