Elimination study of the chemotherapy drug tamoxifen by different advanced oxidation processes: Transformation products and toxicity assessment

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• 作者：Laura Ferrando-Climent^a ; ^b ; Rafael Gonzalez-Olmos^c ; Alba Anfruns^d ; Ignasi Aymerich^a ; Lluis Corominas^a ; Dami&agrave ; Barceló ; ^a ; ^e ; Sara Rodriguez-Mozaz^a ; ^{srodriguez@icra.cat}
• 关键词：Anticancer drugs ; Tamoxifen ; Persistent pollutant ; HRMS ; Advanced oxidation processes ; PCA
• 刊名：Chemosphere
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：168
• 期：Complete
• 页码：284-292
• 全文大小：833 K
• 卷排序：168

文摘

Complete removal of tamoxifen in all the AOP studied. 8 TPs were tentatively identified for the first time. Drastic increase of toxicity along all the experiments. At least one non-ionizable molecule was suspected to be present. Toxicity is due to the presence of TPs.