Metabolic activation of dopamine o-quinones to o-semiquinones by NADPH cytochrome P450 reductase may play an important role in oxidative stress and apoptotic effects
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- 作者：Segura-Aguilar ; Juan ; Metodiewa ; Diana ; Welch ; Christopher J.
- 关键词：Dopamine ; Semiquinone ; Quinone ; NADPH cytochrome P450 reductase ; Cytotoxicity ; Oxidation ; Tyrosinase ; Lactoperoxidase ; Reduction
- 刊名：Biochimica et Biophysica Acta (BBA)/General Subjects
- 出版年：1998
- 出版时间：June 5, 1998
- 年：1998
- 卷：1381
- 期：1
- 页码：1-6
- 全文大小：162 K
文摘
In this study, it is shown that considerable evidence for the possible pathway by which dopamine o-quinone, o-quinone and aminochrome can be activated metabolically by NADPH cytochrome P450 reductase to high reactive semiquinones. These findings were discussed from a mechanistic standpoint as well as in terms of potential physiological implications of dopamine o-quinones and o-semiquinones' concerted action in oxidative stress and apoptotic events.