Edaravone leads to proteome changes indicative of neuronal cell protection in response to oxidative stress
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- 作者：Mohammad-Saeid Jamia ; d ; sjamif@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Zahra Salehi-Najafabadia ; Zahra.salehi@live.com" class="auth_mail" title="E-mail the corresponding author ; Fereshteh Ahmadinejadd ; Fereshte.ahmadi86@ymail.com" class="auth_mail" title="E-mail the corresponding author ; Esthelle Hoedtb ; Esthelle.Hoedt@med.nyu.edu" class="auth_mail" title="E-mail the corresponding author ; esthellehoedt@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Morteza Hashemzadeh Chaleshtorid ; mchalesh@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Mahdi Ghatrehsamanid ; Thomas A. Neubertb ; Thomas.Neubert@med.nyu.edu" class="auth_mail" title="E-mail the corresponding author ; Jan Petter Larsenc ; jpl@sus.no" class="auth_mail" title="E-mail the corresponding author ; Simon Geir Mø ; llera ; c ; mollers@stjohns.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Parkinson's disease ; Edaravone ; Peroxiredoxin-2 ; l-Dopa ; Oxidative stress ; Proteomics
- 刊名：Neurochemistry International
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：90
- 期：Complete
- 页码：134-141
- 全文大小：1263 K
文摘
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Oxidative stress alters proteins involved in neuronal metabolic routes.
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Edaravone reverses H2O2-mediated effects at the protein level.
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Edaravone protects neuronal cells against oxidative stress via Peroxiredoxin-2.