The predictive value of soluble endothelial selectin plasma levels in children with acute lung injury

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• 作者：Mohammed A. Al-Biltagi ; MD ; PhD^a ; ^{mbelrem@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ahmed Abd ElBasset Abo-Elezz ; MD ; PhD^a ; Rasha Mohamed Gamal Elshafiey ; MD ; PhD^a ; Ghada Abudelmomen Suliman ; MD ; PhD^b ; Maaly Mohamed Mabrouk ; MD ; PhD^b ; Hossam Ahmed Mourad ; MSC ; Ped^a
• 关键词：Acute lung injury ; Acute respiratory distress syndrome ; C-reactive protein ; Soluble endothelial selectin ; sE-selectin ; Children
• 刊名：Journal of Critical Care
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：32
• 期：Complete
• 页码：31-35
• 全文大小：211 K

文摘

The study aimed to evaluate the value of soluble endothelial selectin (sE-selectin) plasma level measurement in predicting acute lung injury (ALI) outcome in children.

Methods

The study was a prospective, controlled study that involved 50 children with ALI and 50 healthy children as a control. Soluble endothelial selectin and C-reactive protein plasma levels were measured at days 1 and 7 of development of ALI for the patient group and done only once for the control group.

Results

Plasma sE-selectin was significantly higher in the patients than the control group (P = .001). Mortality reached 32% of children with ALI. The deceased subgroup had significantly higher plasma sE-selectin levels both at days 1 and 7 than the survived (P = .02 and P < .001 respectively). There was positive correlation between plasma sE-selectin at day 7 with durations of both pediatric intensive care unit and mechanical ventilation. Levels of sE-selectin at days 1 and 7 had significant positive correlation with C-reactive protein level and ALI severity. Soluble endothelial selectin plasma levels of 302 ng/mL at day 7 were the best cutoff value to predict ALI-related deaths.

Conclusion

Plasma sE-selectin level served as a good predictor biomarker for both mechanical ventilation duration and the mortality risk in children with ALI.