Plasma concentrations of apolipoproteins A-I, B, and M in patients with critical limb ischemia

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• 作者：Josefin Ahnstr&#xf6 ; m ; Anders Gottsä ; ter ; Bengt Lindblad ; Bj&#xf6 ; rn Dahlbä ; ck
• 关键词：apoA-I ; apoB ; apoM ; CLI ; Atherosclerosis ; HDL ; Cholesterol ; Peripheral arterial disease ; PAD
• 刊名：Clinical Biochemistry
• 出版年：2010
• 出版时间：April 2010
• 年：2010
• 卷：43
• 期：6
• 页码：599-603
• 全文大小：482 K

文摘

Objectives

Apolipoproteins affect development of atherosclerosis, but their involvement in the pathogenesis of critical limb ischemia (CLI), a severe form of atherosclerosis, has not previously been examined.

Design and methods

ApoA-I, apoB, and apoM were measured in plasma from 196 CLI subjects and 214 control individuals from the background population.

Results

Cases had lower levels of the apolipoproteins, as compared to controls; apoA-I, 1.23 vs. 2.08 g/L; apoB, 0.93 vs. 1.04 g/L; apoM, 0.75 vs. 0.91 μmol/L (p < 0.0001 for all three). ApoA-I and apoM correlated negatively with inflammatory markers and positively to 1- and 3-year survival rates, whereas apoB did not. In multivariate analyses, apoA-I, but not apoB and apoM, was independently associated with CLI, the odds ratio being 0.015.

Conclusions

In subjects with CLI, plasma concentrations of apoA-I, apoB and apoM were significantly lower than in control individuals, but only apoA-I was independently associated to CLI.