Excessive apoptosis and defective autophagy contribute to developmental testicular toxicity induced by fluoride
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- 作者：Shun Zhang ; Qiang Niu ; Hui Gao ; Rulin Ma ; Rongrong Lei ; Cheng Zhang ; Tao Xia ; Pei Li ; Chunyan Xu ; Chao Wang ; Jingwen Chen ; Lixing Dong ; Qian Zhao ; Aiguo Wang ; wangaiguo@mails.tjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fluoride ; Reproductive toxicity ; Testis ; Apoptosis ; Autophagy
- 刊名：Environmental Pollution
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：212
- 期：Complete
- 页码：97-104
- 全文大小：2706 K
文摘
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Rats were developmentally exposed to fluoride from pre-pregnancy to post-puberty.
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Both excessive apoptosis and defective autophagy are involved in testicular damage.
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The abnormal apoptosis is mediated by both Fas and mitochondrial pathways.
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The autophagy defect is caused by impaired degradation but not increased formation.