Insight into the role of halogen bond in the activity of d-mandelate dehydrogenase toward halogenated substrates
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- 作者：Fei Guo&dagger ; ; Lidan Ye&dagger ; ; Aipeng Li ; Xiaohong Yang ; Chengcheng Yang ; Hongwei Yu ; yuhongwei@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Protein design ; Dehydrogenase ; Halogen bond ; Mandelic acid ; Halogenated compound
- 刊名：Tetrahedron Letters
- 出版年：2016
- 出版时间：4 May 2016
- 年：2016
- 卷：57
- 期：18
- 页码：1944-1948
- 全文大小：806 K
文摘
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Enzymatic activity toward halogenated compounds may be impeded by the substitution.
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Halogen bond is specific in the complex of proteins and halogenated compounds.
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Halogen bond introduction is an efficient strategy in protein engineering.