Prevalence of CHD-related metabolic comorbidity of diabetes mellitus in Northern Chinese adults: the REACTION study

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• 作者：Nannan Gao^a ; ¹ ; Zhongshang Yuan^a ; ^b ; ¹ ; Xulei Tang^c ; Xiaoming Zhou^d ; Meng Zhao^a ; Lu Liu^a ; Jiadong Ji^b ; Fuzhong Xue^b ; Guang Ning^e ; Jiajun Zhao^a ; Haiqing Zhang^a ; ^{haiqingzhang7576@163.com" class="auth_mail" title="E-mail the corresponding author} ; Ling Gao^a ; ^d ; ^{gaoling1@medmail.com.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Diabetes mellitus ; Metabolic comorbidity ; Coronary heart disease ; Glycemic control ; Cross-sectional study
• 刊名：Journal of Diabetes and its Complications
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：30
• 期：2
• 页码：199-205
• 全文大小：306 K

文摘

To gain more precise understanding of the epidemiology of comorbidities with diabetes and to clarify the correlation with coronary heart disease (CHD) in Chinese population.

Methods

Based on REACTION study, 18,696 participants aged over 40 years were included in the cross-sectional analysis. Prevalence and patterns of comorbid diseases were demonstrated, and their impact on CHD was also analyzed by logistic regression.

Results

Diabetes was more prevalent in patients with older age and lower education level, with relatively low awareness (36.3%), treatment (27.9%) and control (34.7%) rate. The proportion of diabetics with additional condition was 88.8%; 53.2% had more than two comorbidities. Compared with patients with comorbidities, diabetics only had the highest controlled HbA1c rate (37.9%). Dyslipidemia (71.97%) was the most common comorbidity, followed by hypertension (58.19%), and hypothyroidism (21.24%). A strong gradient existed between the number of comorbidities and CHD versus “diabetes only” group; the odds ratio was 1.38, 2.48 and 3.01 for diabetics with one, two and three additional diseases, respectively.

Conclusions

Low glycemic control and high prevalence of diabetes comorbidities are common in China, which increases the risk of CHD. Full-scale and individualized guidelines for diabetics should be planned.