- 作者：Feng Tiana ; 1 ; tianf9721@163.com" class="auth_mail" title="E-mail the corresponding author ; Lei Gub ; 1 ; Aiyong Sic ; Quanbao Yaoa ; Xianwei Zhanga ; Jihui Zhaoc ; zhaojihui07168@163.com" class="auth_mail" title="E-mail the corresponding author ; Daode Hub
- 关键词：AS ; atherosclerosis ; LC-Q-TOF-MS ; liquid chromatography/quadrupole time-of-flight mass spectrometry ; SSKL ; sishen granule ; TCM ; Traditional Chinese Medicine ; BPA ; bisphenol A ; HPLC ; high pressure liquid chromatography ; TC ; total cholesterol ; TG ; total triglycerides ; LDL ; low density lipoprotein receptor ; LC ; liquid chromatography ; ESI ; electrospray ionization ; PCA ; principal component analysis ; PLS-DA ; partial least-squares discriminant analysis ; VIP ; values of variable importance projection ; AN
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2015
- 出版时间：15 December 2015
- 年：2015
- 卷：1007
- 期：Complete
- 页码：140-148
- 全文大小：2735 K
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In this study, fecal extracts from AS mice model were analyzed using a well established metabolomic approach.
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The established metabolomic platform was also used for clearing the effective mechanism of a Traditional Chinese Medicine (TCM) named Sishen granule (SSKL).
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Sixteen potential biomarkers in faeces of AS mice were identified and 5 of them could be reversed by SSKL.
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A network of these identified biomarkers was established. Lipid metabolism, cholesterol metabolism, energy cycle, and inflammation reaction were considered as the most relevant pathological changes in gastrointestinal tract of AS mice.
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This study also demonstrated that SSKL had the therapeutic effectiveness on AS through partly reversing the lipid metabolism, inflammation and energy metabolism.