Bone marrow transplantation modulates tissue macrophage phenotype and enhances cardiac recovery after subsequent acute myocardial infarction
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- 作者：Andrea Prottia ; b ; 1 ; Heloise Mongue-Dina ; 1 ; Katie J. Mylonasc ; Alexander Sirkera ; Can Martin Saga ; d ; Megan M. Swimc ; Lars Maierd ; Greta Sawyera ; Xuebin Donga ; Rene Botnarb ; Jon Salisburye ; Gillian A. Grayc ; Ajay M. Shaha ; ajay.shah@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bone marrow transplantation ; Macrophage polarisation ; Myocardial infarction
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：90
- 期：Complete
- 页码：120-128
- 全文大小：1385 K
文摘
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Bone marrow transplantation (BMT) alters monocyte/macrophage polarisation.
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M2 macrophages are increased in mouse myocardium after BMT.
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Mice that have undergone BMT display reduced remodelling after MI.
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Altered macrophage polarisation after BMT may exert protective effects.
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These effects need to be considered in experiments involving BMT.