Cell-specific effects of Nox2 on the acute and chronic response to myocardial infarction
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- 作者：Alexander Sirker ; Colin E. Murdoch ; Andrea Protti ; Greta J. Sawyer ; Celio X.C. Santos ; Daniel Martin ; Xiaohong Zhang ; Alison C. Brewer ; Min Zhang1 ; Ajay M. Shah ; ajay.shah@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：NADPH oxidase ; Myocardial infarction ; Heart failure ; Cardiac remodeling ; Reactive oxygen species
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：98
- 期：Complete
- 页码：11-17
- 全文大小：988 K
文摘
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ROS contribute to adverse cardiac remodeling after myocardial infarction (MI).
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Nox2 is a major cardiac ROS source but with cell-specific effects.
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Increased Nox2 in cardiomyocytes augments hypertrophy and fibrosis post-MI.
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Increased Nox2 in endothelium has no significant effect on cardiac remodeling after MI.
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Cardiomyocyte Nox2 may have the more important role in post-MI remodeling.