Ruthenium(II) p-cymene complex bearing 2,2′-dipyridylamine targets caspase 3 deficient MCF-7 breast cancer cells without disruption of antitumor immune response

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• 作者：Goran N. Kaluđerović^a ; ^b ; ; Tamara Krajnović^c ; Miljana Momcilovic^c ; Stanislava Stosic-Grujicic^c ; Sanja Mijatović^c ; Danijela Maksimović-Ivanić^c ; Evamarie Hey-Hawkins^a
• 关键词：8505C ; anaplastic thyroid tumor cell line ; 518A2 ; melanoma cell line ; A253 ; head and neck tumor cell line ; AnnV ; annexin V-FITC ; AO ; acridine orange ; CFSE ; carboxyfluorescein diacetate succinimidyl ester ; ConA ; concanavalin A ; CV ; crystal violet ; dpa ; 2 ; 2&prime ; -dipyridylamine ; DMSO ; dimethyl sulfoxide ; DMF ; dimethylformamide ; FCS ; fetal calf serum ; HEPES ; 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid ; IFN-γ ; interferon γ ; IL-10 ; interleukin 10 ; IL-17 ; interleukin 17 ; MCF-7 ; breast tumor ce
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：153
• 期：Complete
• 页码：315-321
• 全文大小：600 K

文摘

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d="p0005">[Ru(η⁶-p-cymene)Cl(dpaR)][PF₆], dpa = 2,2′-dipyridylamine; R = H (dFont">1), (CH₂)₄COOEt (dFont">2).

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d="p0010">Ru(II) complex dFont">1 is more active against tumor cells than dFont">2.

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d="p0015">dFont">1 is the most efficient against caspase 3 deficient MCF-7 breast cancer cells.

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d="p0020">dFont">1 is not active against cells of the adaptive immune system.

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d="p0025">dFont">1 does not exert a general immunosuppressive effect on cytokine production.

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