A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy
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- 作者：Jennifer Davis1 ; L. Craig Davis2 ; Robert N. Correll3 ; Catherine A. Makarewich4 ; Jennifer A. Schwanekamp3 ; Farid Moussavi-Harami1 ; Dan Wang1 ; Allen J. York3 ; Haodi Wu5 ; Steven R. Houser4 ; Christine E. Seidman6 ; Jonathan G. Seidman6 ; Michael Regnier1 ; Joseph M. Metzger7 ; Joseph C. Wu5 ; Jeffery D. Molkentin3 ; 8 ; jeff.molkentin@cchmc.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：19 May 2016
- 年：2016
- 卷：165
- 期：5
- 页码：1147-1159
- 全文大小：2405 K
文摘
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Altered myofilament Ca2+ sensitivity induces heart growth via tension generation
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Increased or decreased myofilament tension induces calcineurin and general growth
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Increased myofilament tension induces ERK1/2 to mediate HCM concentric remodeling
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Modeling the tension integral predicts disease in familial cardiomyopathy patients