Urinary 5-hydroxy indole acetic acid as a test for early diagnosis of acute appendicitis

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• 作者：Bolandparvaz ; Shahram ; Vasei ; Mohammad ; Owji ; Ali Akbar ; Ata-ee ; Negar ; Amin ; Ali ; Daneshbod ; Yahya ; et. al.
• 关键词：U-5-HIAA ; urinary 5-hydroxy indole acetic acid ; 5-HT ; 5-hydroxy tryptamine ; ROC ; receiver operating characteristic ; AUC ; area under curve ; Cr ; creatinine ; AA ; acute appendicitis ; GA ; gangrenous appendicitis ; FH ; follicular hyperplasia ; NA ; non-appendiciti
• 刊名：Clinical Biochemistry
• 出版年：2004
• 出版时间：November, 2004
• 年：2004
• 卷：37
• 期：11
• 页码：985-989
• 全文大小：159 K

文摘

Acute appendicitis (AA) is the most common abdominal emergency. The appendix has abundant serotonin containing cells. Upon inflammation, serotonin is released in the blood and converted into 5-HIAA (5-hydroxy indole acetic acid). Measurement of the urine 5-HIAA (U-5-HIAA) could be a reliable marker of inflammation of the appendix. We have compared the powers of test performance of spot U-5-HIAA and spot U-5-HIAA/creatinin with other routine laboratory tests used for the diagnosis of acute appendicitis.