Pharmacological modulation of astrocytes and the role of cell type-specific histone modifications for the treatment of mood disorders
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- 作者：Mira Jakovcevski1 ; Schahram Akbarian2 ; Barbara Di Benedetto3 ; Barbara.Di-Benedetto@ukr.de" class="auth_mail" title="E-mail the corresponding author ; barbara@mpipsykl.mpg.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Current Opinion in Pharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：26
- 期：Complete
- 页码：61-66
- 全文大小：452 K
文摘
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Astrocytes modulate development and function of synaptic and vascular compartments.
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Dysfunctional astrocytes characterize several mood disorders.
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Histone modifying enzymes are expressed in astrocytes.
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H3K4me3 is differentially regulated in neurons versus astrocytes.
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Pharmacotherapies may target epigenetic marks to rescue astrocytic functionality.