Is cystatin C an evaluative marker for right heart functions in systemic sclerosis?

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• 作者：Oguz Akkus^a ; ^{oakkusfb@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Abdi Bozkurt^b ; ^{abozkurt@cu.edu.tr" class="auth_mail" title="E-mail the corresponding author} ; Didem Arslantas^c ; ^{arslan_didem@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Onur Kaypakli^a ; ^{onurkaypakli@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Durmus Yildiray Sahin^a ; ^{cardiology79@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Halil Aktas^b ; ^{halilaktas_85@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ozlem Goruroglu Ozturk^d ; ^{ozlem_goruroglu@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Fatih Yildiz^c ; ^{drfatih75@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Akgun Yaman^e ; ^{kyaman@cu.edu.tr" class="auth_mail" title="E-mail the corresponding author} ; Eren Erken^c ; ^{eerken@cu.edu.tr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Systemic sclerosis ; NT-proBNP ; Cystatin C ; Right ventricular functions
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：15 October 2016
• 年：2016
• 卷：221
• 期：Complete
• 页码：478-483
• 全文大小：354 K

文摘

Systemic sclerosis (SSc) is a progressive autoimmune disorder with multi-organ involvement. Patients who have SSc are at risk of developing pulmonary arterial hypertension (PAH) and right heart failure. Impaired right heart hemodynamic function is the most powerful predictor of mortality in these patients. We assessed the interactions between levels of NT-proBNP, cystatin C, and right ventricular functions in SSc patients without significant PAH.

bsSec_2">Methods

Fifty SSc patients without significant PAH (37 women and 13 men, mean age 47.2 ± 10.3), and 44 healthy participants as a control group (29 women and 15 men, mean age 47.9 ± 10.4) were included in the study.

bsSec_3">Results

Cystatin C and NT-proBNP levels were significantly higher in patients with SSc. Both cystatin C and NT-proBNP levels possitively correlate with age, interventricular septum thickness, left ventricular posterior wall thickness, systolic pulmonary artery pressure, the peak late diastolic filling velocity, tricuspid regurgitation velocity, and negatively correlate with pulmonary artery acceleration time in the patients.

bsSec_4">Conclusions

Our results showed that elevated cystatin-C and NT-proBNP levels may be a clue for diastolic impairment in right ventricular functions in SSc.