Synthesis, antibacterial activity and QSAR studies of 1,2-disubstituted-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines
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- 作者：Rakesh Kumar Tiwari ; Devender Singh ; Jaspal Singh ; Anil Kumar Chhillar ; Ramesh Ch ; ra ; Akhilesh Kumar Verma
- 关键词：1 ; 2 ; 3 ; 4-Tetrahydroisoquinolines ; Antibacterial activity ; Linear free energy relationship (LFER) ; QSAR
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2006
- 出版时间：January 2006
- 年：2006
- 卷：41
- 期：1
- 页码：40-49
- 全文大小：353 K
文摘
Some new substituted-tetrahydroisoquinoline derivatives were synthesized and evaluated for their in vitro antimicrobial activities against the standard Gram positive and Gram negative strains: Staphylococcus aureus (ATCC 25923), S. epidermidis (WHO-6), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 4a–c proved to be effective with MIC 3.5–20 (μg ml–1). Quantitative structure activity relationship (QSAR) studies with multiple linear regression analysis were applied to find correlation between different calculated molecular descriptors of the synthesized compounds and biological activity.