Determinative role of N-myc in differentiation of the neural crest

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• 作者：Kondoh ; Hisato ; Wakamatsu ; Yoshio ; Shimono ; Akihiko
• 刊名：Neuroscience Research
• 出版年：2001
• 出版时间：December, 2001
• 年：2001
• 卷：25
• 期：Supplement 1
• 页码：S2
• 全文大小：49.0 K

文摘

N-myc is expressed primarily during embryogenesis, in particular in the neural crest and its derivatives. Neural crest cells initially express N-myc uniformly, but later only the populations undergoing differentiation into neurons or adrenomedulla exhibit a significant level of N-myc expression. Forced expression of N-myc above endogenous level in migrating neural crest resulted in premature differentiation of neurons, indicating that high N-myc expression drives the neural crest cells to the neuronal pathway of differentiation.