Protective effects of edaravone against ischemia-induced facial palsy

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• 作者：Taizo Takeda ; Setsuko Takeda ; Masaya Takumida ; Teruhiko Okada ; Akinobu Kakigi ; Hiroaki Nakatani ; Masashi Hamada ; Kazuhiro Yamakawa
• 关键词：Ischemia ; Acute facial palsy ; Reactive oxygen species (ROS) ; Free radical scavenger ; Edaravone
• 刊名：Auris Nasus Larynx
• 出版年：2008
• 出版时间：September 2008
• 年：2008
• 卷：35
• 期：3
• 页码：321-327
• 全文大小：1435 K

文摘

Objective

The protective effect of edaravone, an inhibitor of reactive oxygen species (ROS), against the development of ischemia-induced facial palsy was investigated.

Methods

Experimental ischemic facial palsy was induced by interruption of the petrosal artery (PA) in guinea pigs. The application of edaravone was carried out by daily intraperitoneal injection for 1 week. The behavioral facial movement, fluorescence intensity of ROS, and morphological changes were investigated.

Results

Edaravone injection from immediately after PA interruption significantly reduced dihydrotetramethylrosamine fluorescence intensity (indicative of ROS) in the facial nerve of the interrupted ear and attenuated the development of ischemia-induced facial palsy. Edaravone injection from the 2nd day following PA interruption also reduced the incidence of facial palsy. Light and electron microscopy revealed that edaravone application tended to prevent the degenerative changes of the facial nerve caused by ischemia.

Conclusions

Edaravone suppressed the production of ROS and had a remarkable protective effect against the development of mild to moderate facial palsy. Morphologically, nerve damage was also decreased by edaravone injection.