Histomorphometric analysis of minimodeling in the vertebrae in postmenopausal patients treated with anti-osteoporotic agents

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• 作者：Tomohiro Hikata^a ; ^b ; Tomoka Hasegawa^c ; Keisuke Horiuchi^a ; ^{horiuchi@z3.keio.jp} ; Nobuyuki Fujita^a ; Akio Iwanami^a ; Kota Watanabe^a ; Ken Ishii^a ; Masaya Nakamura^a ; Norio Amizuka^c ; Morio Matsumoto^a
• 关键词：Minimodeling ; Osteoporosis ; Eldecalcitol ; Bisphosphonates
• 刊名：Bone Reports
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：5
• 期：Complete
• 页码：286-291
• 全文大小：1033 K
• 卷排序：5

文摘

We aimed to evaluate the potential effects of a new vitamin D3 analog, Eldecalcitol and BPs on minimodeling in humans using surgical specimens. We found that minimodeling is readily observed in the humans. We found that patients who had been treated with Eldecalcitol prior to surgery tend to have increased minimodeling activity. Our data indicate that Eldecalcitol can activate minimodeling in patients with post-menopausal osteoporosis while bisphosphonates have negative or little impact on this form of bone formation.