The methylation status of FBXW7 β-form
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- 作者：Zhaodi Gu ; Hidetoshi Mitsui ; Kenichi Inomata ; Masako Honda ; Chiaki Endo ; Akira Sakurada ; Masami Sato ; Yoshinori Okada ; Takashi Kondo ; Akira Horii
- 关键词：Methylation ; FBXW7 β ; -form ; Thymoma
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2008
- 出版时间：12 December 2008
- 年：2008
- 卷：377
- 期：2
- 页码：685-688
- 全文大小：281 K
文摘
FBXW7 is reported to be a tumor suppressor gene, and the functional inactivation of FBXW7 has been reported in various human tumors. In this study, we investigated the FBXW7 gene in human thymoma; although no mutations were evident, a significantly high frequency of methylation in the FBXW7 β-form promoter was observed in types B1 or higher (P = 0.014). We propose a novel mechanism for the pathogenesis of thymoma by FBXW7 β-form and hypothesize that expressional suppression plays an important role in the malignant potential of thymoma.