Alcohol Consumption and Multiple Dysplastic Lesions Increase Risk of Squamous Cell Carcinoma in the Esophagus, Head, and Neck

详细信息    查看全文

• 作者：Chikatoshi Katada¹ ; Tetsuji Yokoyama² ; Tomonori Yano³ ; Kazuhiro Kaneko³ ; Ichiro Oda⁴ ; Yuichi Shimizu⁵ ; Hisashi Doyama⁶ ; Tomoyuki Koike⁷ ; Kohei Takizawa⁸ ; Motohiro Hirao⁹ ; Hiroyuki Okada¹⁰ ; Takako Yoshii¹¹ ; Kazuo Konishi¹² ; Takenori Yamanouchi¹³ ; Takashi Tsuda¹⁴ ; Tai Omori¹⁵ ; Nozomu Kobayashi¹⁶ ; Tadakazu Shimoda¹⁷ ; Atsushi Ochiai¹⁸ ; Yusuke Amanuma¹⁹ ; Shinya Ohashi¹⁹ ; Tomonari Matsuda²⁰ ; Hideki Ishikawa²¹ ; Akira Yokoyama²² ; Manabu Muto¹⁹ ; ^{mmuto@kuhp.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Drinking Alcohol ; Carcinogenesis ; Risk Factor ; Genetics Methods
• 刊名：Gastroenterology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：151
• 期：5
• 页码：860-869.e7
• 全文大小：2506 K

文摘

Some patients develop multiple squamous cell carcinomas (SCCs) in the upper aerodigestive tract, attributed to field cancerization; alcohol consumption has been associated with this process. We examined the association between multiple areas of dysplastic squamous epithelium with the development of SCC of the esophagus or head and neck cancer, as well as alcohol consumption and smoking.

Methods

We examined 331 patients with early stage esophageal SCC using Lugol chromoendoscopy to evaluate the dysplastic squamous epithelium in the esophagus. Patients then were assigned to 3 groups, based on the number of Lugol-voiding lesions: A, no lesion; B, 1–9 lesions; or C, 10 or more lesions. Participants completed lifestyle surveys on their history of drinking, smoking, and diet. All participants were evaluated by laryngopharyngoscopy before registration; only those without head and neck cancer were included, except for patients with superficial SCC limited to the subepithelial layer. Lesions detected in the esophagus and head and neck by surveillance were considered to be metachronous. The study end point was the cumulative incidence of metachronous SCCs in the esophagus and head and neck after endoscopic resection of esophageal SCC, according to the grade of Lugol-voiding lesions. At study entry, all patients were instructed to abstain from alcohol and smoking.

Results

Over the 2-year study period, metachronous SCCs of the esophagus were detected in 4% of patients in group A, in 9.4% of patients in group B, and in 24.7% of patients in group C (P < .0001 for patients in group A vs B or B vs C). Head and neck SCCs were detected in none of the patients in group A, in 1.7% of the patients in group B, and in 8.6% of the patients in group C (P = .016 for patients in group A vs C and P = .008 for patients in group B vs C). SCC of the esophagus or head and neck developed in 4.0% of patients in group A, in 10.0% of patients in group B, and in 31.4% of patients in group C (P < .0001 for group A vs B or A vs C). Alcohol abstinence decreased the risk of multiple SCCs of the esophagus (adjusted hazard ratio, 0.47, 95% confidence interval, 0.25–0.91; P = .025), whereas smoking abstinence did not.

Conclusions

Multiple dysplastic lesions in the esophagus increase the risk of multiple SCCs. Alcohol abstinence reduces the risk of metachronous SCCs. Clinical Trials registry: UMIN000001676 and UMIN000005466.