Epstein-Barr virus-positive mucocutaneous ulcer arising in a post-hematopoietic cell transplant patient followed by polymorphic posttransplant lymphoproliferative disorder and cytomegalovirus colitis

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• 作者：Akira Satou ; MD ; PhD^a ; ^b ; ^c ; ^{sato.akira@med.nagoya-u.ac.jp} ; Akio Kohno ; MD ; PhD^d ; Ryuichi Fukuyama ; MD ; PhD^c ; Ahmed Ali Elsayed ; MD ; PhD^a ; ^e ; Shigeo Nakamura ; MD ; PhD^a
• 关键词：EBV+ mucocutaneous ulcer ; Hematopoietic cell transplant ; EBV+ posttransplant lymphoproliferative disorder ; Immunodeficiency
• 刊名：Human Pathology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：147-151
• 全文大小：1459 K
• 卷排序：59

文摘

Epstein-Barr virus (EBV)–positive mucocutaneous ulcer (EBVMCU) is a newly described entity occurring in elderly or iatrogenically immunocompromised patients. We describe a case of EBVMCU arising in a post–hematopoietic cell transplant patient and followed by EBV-positive polymorphic posttransplant lymphoproliferative disorder (EBV+ polymorphic PTLD). The patient, a 52-year-old woman, received chemotherapy and autologous peripheral blood stem cell transplantation for relapsed diffuse large B-cell lymphoma (DLBCL). She achieved complete remission and was followed up in an outpatient clinic after discharge. One year later, EBVMCU appeared in the tongue and exhibited spontaneous regression. Six months after the regression of the EBVMCU, she had EBV+ polymorphic PTLD, analogous to EBV+ polymorphic DLBCL. The therapy for PTLD was not effective, and the patient finally died of disease progression. This was the first case of EBVMCU characterized by both an association with autologous peripheral blood stem cell transplantation and subsequent emergence of malignant lymphoma in a patient with relapsed DLBCL.