Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity

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• 作者：Patrí ; cia de Araú ; jo Pereira^a ; ¹ ; Antó ; nio Marcos Alvim-Soares Jr.^a ; ¹ ; ^{antonioalvimjr@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Valé ; ria Cristina Sandrim^d ; Carla Má ; rcia Moreira Lanna^c ; Dé ; bora Cristine Souza-Costa^b ; Vanessa de Almeida Belo^b ; Jonas Jardim de Paula^a ; José ; Eduardo Tanus-Santos^b ; Marco Auré ; lio Romano-Silva^a ; Dé ; bora Marques de Miranda^a
• 关键词：Single-nucleotide polymorphisms ; Childhood obesity ; Fat mass and obesity associated ; Gene ; AKT1 ; AKTIP
• 刊名：Jornal de Pediatria
• 出版年：2016
• 出版时间：September-October 2016
• 年：2016
• 卷：92
• 期：5
• 页码：521-527
• 全文大小：635 K

文摘

Obesity is a chronic disease caused by both environmental and genetic factors. Epidemiological studies have documented that increased energy intake and sedentary lifestyle, as well as a genetic contribution, are forces behind the obesity epidemic. Knowledge about the interaction between genetic and environmental components can facilitate the choice of the most effective and specific measures for the prevention of obesity. The aim of this study was to assess the association between the FTO, AKT1, and AKTIP genes and childhood obesity and insulin resistance.

Methods

This was a case–control study in which SNPs in the FTO (rs99396096), AKT1, and AKTIP genes were genotyped in groups of controls and obese/overweight children. The study included 195 obese/overweight children and 153 control subjects.

Results

As expected, the obese/overweight group subjects had higher body mass index, higher fasting glucose, HOMA-IR index, total cholesterol, low-density lipoprotein, and triglycerides. However, no significant differences were observed in genes polymorphisms genotype or allele frequencies.

Conclusion

The present results suggest that AKT1, FTO, and AKTIP polymorphisms were not associated with obesity/overweight in Brazilians children. Future studies on the genetics of obesity in Brazilian children and their environment interactions are needed.