AKT1 has dual actions on the glucocorticoid receptor by cooperating with 14-3-3

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• 作者：Tanwir Habib^a ; ^{thabib@sidra.org} ; Ameera Sadoun^b ; ^{asadoun@sidra.org} ; Nancy Nader^c ; ^{nan2017@qatar-med.cornell.edu} ; Shigeru Suzuki^d ; ^e ; ^{shige5p@asahikawa-med.ac.jp} ; Wei Liu^f ; ^{wliu@sidra.org} ; Puthen V. Jithesh^a ; ^{PJithesh@sidra.org} ; Tomoshige Kino^b ; ^d ; ^{tkino@sidra.org}
• 关键词：Histone modification ; Nuclear translocation ; Phosphorylation ; Protein-protein interaction ; Transcriptomics
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：431-443
• 全文大小：1709 K
• 卷排序：439

文摘

AKT has 2 distinct actions on GR transcriptional activity in corporation with 14-3-3. One is segregation of GR in the cytoplasm through phosphorylation binding of GR to 14-3-3. The other is direct activation of GR transcriptional activity in the nucleus cooperating with 14-3-3. Specific modulation of these 2 actions of AKT1/14-3-3 is beneficial for ALL treatment.