HAdV-2-suppressed growth of SV40 T antigen-transformed mouse mammary epithelial cell-induced tumours in SCID mice
详细信息 查看全文
- 作者：Chengjun Wua ; 1 ; 2 ; Xiaofang Caoa ; 1 ; Di Yub ; Elisabeth J.M. Huijbersa ; 3 ; Magnus Essandb ; Gö ; ran Akusjä ; rvia ; Staffan Johanssona ; Catharina Svenssona ; cath@imbim.uu.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：Oncolytic adenovirus ; Murine cells ; Anti-tumour activity ; Permissive infection ; Viral replication
- 刊名：Virology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：489
- 期：Complete
- 页码：44-50
- 全文大小：2949 K
文摘
- •
A tumorigenic mouse cell line NMuMG-T was fully permissive for adenovirus replication.
- •
Injection of HAdV-2 repressed growth of NMuMG-T-established tumours in SCID mice.
- •
Viral DNA and late viral proteins was observed three weeks after the final injection of HAdV-2.
- •
HAdV-2 injected tumours showed signs of disintegrated structure and possibly cell death.