The transcriptional co-activator proteins p300 and CBP stimulate adenovirus E1A conserved region 1 transactivation-independent of a direct interaction

详细信息    查看全文

• 作者：Mannervik ; Mattias ; Akusj&auml ; rvi ; Gö ; ran
• 关键词：p300 ; CBP ; Transcription activation ; Adenovirus E1A
• 刊名：FEBS Letters
• 出版年：1997
• 出版时间：September 1, 1997
• 年：1997
• 卷：414
• 期：1
• 页码：111-116
• 全文大小：582 K

文摘

p300 and CBP are two related transcriptional co-activator proteins required by many cellular transcription factors for activity. The adenovirus E1A protein binds p300 and CBP through its amino-terminus and conserved region (CR) 1. Fusing CR1 to a heterologous DNA-binding domain creates a potent transcriptional activator, suggesting that CR1 might activate transcription by recruiting p300/CBP to the promoter. We show that both p300 and CBP enhances CR1-dependent transactivation. However, this enhancement occurs independently of a direct interaction with E1A and does not correlate with the CR1 activator function.